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Inventi Impact: Gastroenterology

Articles

  • Inventi:hls/18317/15
    Molecular Features and Methylation Status in Early Onset (â?¤40 Years) Colorectal Cancer: A\nPopulation Based, Case-control Study
    01-Jan-1970 Research 2016 : January - March
    Giulia Magnani, Daniela Furlan, Nora Sahnane, Luca Reggiani Bonetti, Federica Domati, Monica Pedroni

    Colorectal cancer is usually considered a disease of the elderly. However, a small fraction of patients develops colorectal cancer\nearlier. The aim of our study was to define the frequency of known hereditary colorectal syndromes and to characterise genetic\nand epigenetic features of early nonhereditary tumors. Thirty-three patients �40 years with diagnosis of colorectal cancer and\n41 patients with disease at >60 years of age were investigated for MSI, Mismatch Repair proteins expression, KRAS and BRAF\nmutations, hypermethylation, and LINE-1 hypomethylation. Detection of germline mutations was performed inMismatch Repair,\nAPC and MUTYH genes. Early onset colorectal cancer showed a high incidence of hereditary forms (18%). KRAS mutations were\ndetected in 36% of early nonhereditary tumors. Early onset colorectal cancer disclosed an average number of methylated genes\nsignificantly lower when compared to the controls (

    How to Cite this Article
    CC Compliant Citation: Giulia Magnani, Daniela Furlan, Nora Sahnane, Luca Reggiani Bonetti, Federica Domati, and Monica Pedroni,\nâ??Molecular Features and Methylation Status in Early Onset (40 Years) Colorectal Cancer: A Population Based, Case-Control Study,â?\nGastroenterology Research and Practice, vol. 2015, Article ID 132190, 10 pages, 2015. doi:10.1155/2015/132190, http://\ncreativecommons.org/licenses/by/3.0/.
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